2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-121394
    L-659,989 113787-28-3 98%
    L-659,989 is an orally active, extremely potent, selective and competitive platelet activating factor (PAF) receptor antagonist.
    L-659,989
  • HY-121460
    Spiraprilat 83602-05-5 98%
    Spiraprilat is a potent angiotensin-converting enzyme (ACE) inhibitor. Spiraprilat has ability to improve left ventricular (LV) function and metabolism in anesthetized open-chest dogs with acute ventricular failure (ALVF).
    Spiraprilat
  • HY-121519
    GSK2332255B 1366233-41-1 98%
    GSK2332255B is a potent, selective TRPC3 and TRPC6 antagonist with IC50s of 5 nM and 4 nM for rat TRPC3 and rat TRPC6. GSK2332255B shows ≥100-fold selectivity for TRPC3/6 over other calcium-permeable channels.
    GSK2332255B
  • HY-121520
    Docosahexaenoyl glycine 132850-40-9 98%
    Docosahexaenoyl glycine is a PUFA analogue. Docosahexaenoyl glycine has activating effects on IKs channels and restore the function of IKs channels with LQT1 mutation.
    Docosahexaenoyl glycine
  • HY-121550
    ME3221 139958-16-0 98%
    ME3221 is an angiotensin AT1 receptor antagonist that effectively antagonizes the pressor response to angiotensin II in rats and marmosets without affecting the hypotensive response to bradykinin. It demonstrates potent antihypertensive effects in renal hypertensive rats and spontaneously hypertensive rats (SHR), with efficacy comparable to or better than losartan in vivo. ME3221's repeated administration in SHR results in sustained and stable hypotensive effects without affecting heart rate, indicating its potential for treating both renal and essential hypertension similarly to losartan.
    ME3221
  • HY-121586
    Nafazatrom 59040-30-1 98%
    Nafazatrom (Bay g 6575) is an orally active cardioprotective agent that protects against ischemic damage. Nafazatrom dose-dependently inhibits neutrophil aggregation, superoxide anion generation, arachidonic acid metabolism, and to a lesser extent the release of β-glucosidase, platelet aggregation or arachidonic acid in vitro. Acid metabolism has no significant effect. In a dog ischemia-reperfusion model, Nafazatrom (10 mg/kg; po) reduced infarct size and the occurrence of arrhythmias and rescued ischemic myocardial function without affecting any hemodynamic changes. The basis of Nafazatrom's cardioprotection may be inhibition of neutrophil function and cellular infiltration in vitro.
    Nafazatrom
  • HY-121598
    Actisomide 96914-39-5 98%
    Actisomide (SC-36602) is an antiarrhythmic agent. Absorption of actisomide in rats and its in vitro uptake in CaCo-2 cells are pH-dependent.
    Actisomide
  • HY-121609
    Pholedrine 370-14-9 98%
    Pholedrine, the main metabolite of methamphetamine, is an indirectly acting sympathomimetic amine. Pholedrine is a cardiovascular agent exerting hypertensive and adrenergic effects. Pholedrine can produce mydriatic response and allow localization of the site of the interruption in the oculosympathetic pathway. Pholedrine can be used as a topical eye drop and a diagnostic agent for use in Horner's syndrome.
    Pholedrine
  • HY-121617
    Bucainide 51481-62-0 98%
    Bucainide (RHC G-233) is an antiarrhythmic agent that enables the determination of Bucainide in plasma using the GLC method.
    Bucainide
  • HY-121690
    Semotiadil 116476-13-2 98%
    Semotiadil (SD-3211), a benzothiazine compound, is a Ca2+ antagonist. Semotiadil exerts antiplatelet activity.
    Semotiadil
  • HY-121692
    (S)-Alprenolol 23846-71-1 98%
    (S)-Alprenolol is a potent and nonselective β-blocker.
    (S)-Alprenolol
  • HY-121710
    MonoHER 23869-24-1
    MonoHER (7-Monohydroxyethylrutoside) is a Carbonyl reductase 1 (CBR1) inhibitor and can be used as a cardioprotective agent. MonoHER inhibits the activity of CBR1 V88 and CBR1 I88 in a concentration-dependent manner.
    MonoHER
  • HY-121726
    3HOI-BA-01 355428-84-1 98%
    3HOI-BA-01 is amTORinhibitor.3HOI-BA-01reduces infarct size and inducedautophagyin a murine myocardial ischemia/reperfusion injury model.
    3HOI-BA-01
  • HY-121746
    GW7845 196809-22-0 98%
    GW7845 is an orally active non-thiazolidinedione, tyrosine-derived PPARγ agonist. GW7845 is effective at inhibiting voltage-dependent calcium channels (VDCC) and relaxing pressurized arteries with IC50 of 3 μM by using Ba2+ as the charge carrier through VDCC. GW7845-induced apoptosis is mitochondria- and apoptosome-dependent. GW7845 induces rapid mitochondrial membrane depolarization and release of cytochrome c in primary pro-B cells and BU-11 cells.
    GW7845
  • HY-121776
    Nicomol 27959-26-8 98.40%
    Nicomol is an orally active hypolipidemic agent that can increase the high density lipoprotein cholesterol (HDL-C) level. Nicomol inhibits the rapid rise of plasma free fatty acids.
    Nicomol
  • HY-12177S
    Aliskiren-d6 hemifumarate 98%
    Aliskiren-d6 (hemifumarate) is a deuterium labeled Aliskiren hemifumarate. Aliskiren hemifumarate is a direct and orally active renin inhibitor with an IC50 of 1.5 nM.
    Aliskiren-d6 hemifumarate
  • HY-121825
    U-44069 56985-32-1 98%
    U-44069 is a stable prostaglandin (PG) H2 analogue and a potent vasoconstrictor. U-44069 induces Ca influx at preglomerular vessels.
    U-44069
  • HY-121985
    Protheobromine 50-39-5 98%
    Protheobromine is a cardiotonic and bronchodilator
    Protheobromine
  • HY-122040
    5-Chloro hydrochlorothiazide 5233-42-1 98%
    5-Chloro hydrochlorothiazide is a derivative of hydrochlorothiazide (HY-B0252), and has diuretic action.
    5-Chloro hydrochlorothiazide
  • HY-122048
    AR-C67085 164992-25-0 98%
    AR-C67085 (PSB 0413; FPL 67085) is a potent platelet P2T receptor antagonist with an pIC50 value of 8.60. AR-C67085 inhibits ADP-induced platelet aggregation.
    AR-C67085
Cat. No. Product Name / Synonyms Application Reactivity